- Eddie McClintock as Peter Lattimer (13/13 episodes)
- Joanne Kelly as Myka Bering (13/13 episodes)
- Saul Rubinek as Arthur Nielsen (13/13 episodes)
- Genelle Williams as Leena (7/13 episodes)
- Allison Scagliotti as Claudia Donovan (13/13 episodes)
- Jaime Murray as Helena G. Wells (6 episodes)
- CCH Pounder as Irene Frederic (5 episodes)
- Paula Garces as Kelly Hernandez (5 episodes)
- Nolan Gerald Funk as Todd (4 episodes)
- Mark Sheppard as Benedict Valda (3 episodes)
- Roger Rees as James MacPherson (2 episodes)
- Faran Tahir as Adwin Kosan (2 episodes)
- Lindsay Wagner as Vanessa Calder (2 episodes)
- Tia Carrere as Kate Logan (2 episodes)
- Cody Rhodes as Kurt Smoller
- Rene Auberjonois as Hugo Miller (1 episode)
- Simon Reynolds as Daniel Dickinson (1 episode)
- Neil Grayston as Douglas Fargo
- Jewel Staite as Loretta
- Sean Maher as Sheldon
- Judd Hirsch as Isadore Weisfelt
- Philip Winchester as Raymond St. James
- René Auberjonois as Hugo Miller
|Time Will Tell||Writer: Jack Kenny||Director: Stephen Surjik||July 6, 2010||#1|
|MacPherson frees H. G. Wells and escapes the Warehouse with the aid of Leena. The agents try to track down MacPherson and Wells again.
|Mild Mannered||Writer: Benjamin Raab & Deric A. Hughes||Director: Constantine Makris||July 13, 2010||#2|
|When a masked vigilante dispenses superhero-style justice in Detroit, Myka and Pete search for the artifact responsible. Claudia and Leena sort out their animosity while installing motion detectors throughout the Warehouse, and Artie tries to figure out how and why he's apparently being haunted by MacPherson.
|Beyond Our Control||Writer: David Simkins||Director: Constantine Makris||July 20, 2010||#3|
|Pete, Myka, Artie and Claudia investigate a series of seemingly random appearances of men from different historical periods occurring in Univille. Meanwhile, Irene Frederic and the Regents help Leena overcome the mental and physical consequences of MacPherson's possession.
|Age Before Beauty||Writer: Daniel Kreisberg||Director: Tawnia McKiernan||July 27, 2010||#4|
|The team investigates the death of a Russian model who rapidly aged. They head for New York City to go to a model show where Pete Lattimer witnesses another model rapidly age. Meanwhile Claudia goes on a date with Todd which doesn't end well.
|13.1||Writer: Jack Kenny & David Simkins||Director: Ken Girotti||August 3, 2010||#5|
|Dr. Douglas Fargo a scientist employed by Global Dynamics located in Eureka, Oregon travels to Warehouse 13 to update its computer system. During the process a computer virus is triggered that causes a lockdown of the Warehouse, trapping everyone inside.
|Around The Bend||Writer: Bob Goodman||Director: Tawnia McKiernan||August 10, 2010||#6|
|Pete has a secret assignment, and runs into a former flame, which may result in him betraying the team.
|For The Team||Writer: Drew Z. Greenberg||Director: Tawnia McKiernan||August 17, 2010||#7|
|Myka teams up with a new partner to investigate into combustible college wrestlers.
|Merge With Caution||Writer: Nell Scovell||Director: Anton Cropper||August 24, 2010||#8|
|Pete and Myka's bodies are swapped because of an artifact. Soon after, they find out that the swap is deadly. In the meantime, Claudia and Artie investigate into a seduction artifact to which Artie falls prey.
|Vendetta||Writer: Michael P. Fox||Director: Matt Earl Beesley||August 31, 2010||#9|
|Artie's past as a traitor returns to haunt him when someone uses artifacts to murder, and his former Russian handler is the prime suspect.
|Where and When||Writer: Drew Z. Greenberg & Andrew Kreisberg||Director: Stephen Cragg||September 7, 2010||#10|
|The group must use Helena's time machine to travel to 1961 to solve a case.
|Buried||Writer: Robyn Adams & Mike Johnson||Director: Stephen Surjik||September 14, 2010||#11|
|When Mrs. Frederic starts speaking a dead language, the team discovers that the remnants of Warehouse 2 have been discovered during an archeological dig in Egypt.
|Reset||Writer: Jack Kenny & Nell Scovell||Director: Constantine Makris||September 21, 2010||#12|
|The team tries to track down their rogue member, and discover the artifact they have is unexpectedly powerful. Meanwhile, Claudia wonders about her future with the Warehouse team and Pete must choose between Kelly and the mission.
|Secret Santa||Writer: Bob Goodman||Director: Jack Kenny||December 7, 2010||#13|
|Pete and Myka have to track down a bad Santa while the rest of the team celebrates the holidays.
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